MajorinterestsOptimization,Statistics,AlgorithmandMachineLearningforKnowledgeDiscoveryBioinformaticsandComputationalBiologyCancergenomicsEpigenomicsNetworkbiology2Epigenetics3Non-DNAsequencerelated,heritablemechanismstocontrolgeneexpressions.DNAmethylation(DNA甲基化)4AnepigeneticmodificationoftheDNAsequence:addingamethylgrouptothe5positionofcytosine(5mC)PrimarilyhappensatCpGsites(CfollowedbyaG),althoughnon-CGmethylationexists•Inhumangenome,~90%ofCpGsitesarefullymethylated,exceptatCpGislandswheremethylationlevelsaretypicallylow•MethylationofCpGislandsin/nearpromoterregionofgenecansilencegeneexpression.•DNAmethylationhashightissue-specificity.O...