924CANCERDISCOVERYAPRIL2022AACRJournals.orgREVIEWExpandingtheReachofPrecisionOncologybyDruggingAllKRASMutantsMarcoH.Hofmann1,DanielGerlach1,SandraMisale2,MarkPetronczki1,andNorbertKraut1ABSTRACTKRASisthemostfrequentlymutatedoncogene,harboringmutationsinapprox-imatelyoneinsevencancers.Allele-specificKRASG12CinhibitorsarecurrentlychangingthetreatmentparadigmforpatientswithKRASG12C-mutatednon–smallcelllungcancerandcolorectalcancer.ThesuccessofaddressingapreviouslyelusiveKRASallelehasfueleddrugdiscoveryeffortsforallKRASmutants.Pan-KRASdrugshavethepotentialtoaddressbroadpatientpopula-tions,includingKRASG12D-,KRASG12V-,KRASG13D-,KRASG12R-,andKRASG12A-mutantorK...